安进(AMGN.US)AMG 133启动减重III期临床

智通财经03-07

智通财经APP获悉，3月5日，全球临床试验收录网站clinicaltrials显示，安进(AMGN.US)启动了AMG 133(Maridebart Cafraglutide，MariTide)的两项III期临床试验(MARITIME-1和MARITIME-2)，标志着AMG 133进入III期开发阶段。

AMG133是安进自主研发的一款注射频率可达到每4周1次的first-in-class抗体多肽偶联药物，由靶向葡萄糖依赖性促胰岛素释放多肽受体(GIPR)的全人源单抗偶联两个GLP-1类似物而成，通过抑制GIPR并激活GLP-1受体(GLP-1R)来发挥减少食物摄入和调节代谢进而减轻体重和降低血糖的作用。

AMG 133的降糖和减重效果已经在II期研究中得到了初步验证。

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